"Site-restricted conjugation of native mAbs offers the best of two worlds"

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Management

The LinXis management team has a highly credible track record in medicine, antibody technology, oncology, tumor immunology and pathology as well as in business competencies like company management, IP management, finance, business development and deal making. Importantly, the team has a high quality network in global pharma and biotech companies and investors.

LinXis team

To support the management LinXis has installed an Advisory Board with internationally renowned experts whose combined competences cover the whole range of drug development, preclinical and clinical evaluation and business development of the LinXis product pipeline.


Board

Board, CEO/CSO

HendrikJan Houthoff (1943; MD, PhD, Prof emeritus) is founder of LinXis. He devotes his time to the company’s general management and scientific strategy. He has been full professor in human pathology at several Dutch universities (1970-1989) and founder, CEO and CSO of Kreatech Biotechnology (1990-2003). Under his supervision, Kreatech started in 2002 with European research projects in the development of targeted drugs for the treatment of liver cirrhosis and kidney fibrosis. With LinXis HendrikJan continues the research on drug targeting technologies.

Board, Chief Marketing Officer

Gerro van Rheenen (1956; MD) has been a valuable part of the LinXis management team since 2014 and devotes his time to marketing and sales management.

He started his career as a general practitioner with a profound interest in Medical Sciences. He has an entrepreneurial, marketing and sales background in medical and customer care products and was founder and CEO of several customer care companies. He combines analytical and creative thinking with a cooperative character that enables him to mediate LinXis’ partnering and networking activities.

Board, Chief Business Officer

Paul Steverink (1962; DVM, PhD) is responsible for LinXis’ finance and business & corporate development. He holds a PhD in immunology and headed the vaccine development group for endemic diseases and IP and licensing department at ID Lelystad. In addition he has an MBA from Erasmus University, Rotterdam, with a focus on corporate finance. He has taken the lead in (financially) structuring several international commercial transactions, in particular transactions with significant intellectual property components. Paul has been and is CFO of a variety of biotech companies.


Advisory board

Advisory board

Guus van Dongen (1956; PhD, Prof) is an invaluable advisor to LinXis with his scientific and medical expertise in imaging and antibody development. He advises and steers the LinXis research team on a daily and stand-by basis.

As a professor at the VUmc Department of Radiology & Nuclear Medicine, Tracer Center Amsterdam, and project leader of the VU University Medical Imaging Center, Amsterdam, he has become an international expert in preclinical and clinical molecular imaging, in the development of monoclonal antibodies (mAbs) and antibody conjugates like ADCs, and in the in the image-guided (pre)clinical evaluation of new targeted drugs. His department serves many leading biotech, pharma and imaging companies, as well as innovative start-ups, and has brought > 25 antibody conjugates, prepared in own licensed GMP facilities, in first-in-human studies. He is (co)author of > 180 peer-reviewed papers, h-index 44, and is inventor at several patents.

Advisory board

Jan Reedijk is professor emeritus at the Leiden Institute Chemistry, of Leiden University. He is a highly renowned international expert in platinum chemistry, metal coordination by ligands and metal applications in medicine. He has well over 1200 (co-)authored refereed research publications and patents (1965 - 2015). During his academic career he has supervised over 250 MSc student projects, over 90 postdocs and 90 graduate students (1973-2011). His h-index (WoS spring 2015) is listed as 85. He has served or is still serving in over 15 editorial boards of scientific journals.

A selection of major honors includes: (1) Awarded of the Max Planck Research Award in Chemistry (1992). (2) Elected Member of the Royal Netherlands Academy of Sciences (1996), (3) Elected Member Finnish Academy of Sciences (1997); (4) Elected Member of the Academia Europaea (2003); (5) Honorary fellow of the Royal Netherlands Chemical Society (2003); (6) Royal Knighthood to the order of the Dutch Lion (2008).

Advisory board

H.M. Bob Pinedo, MD, PhD, is professor emeritus of Medical Oncology at the VU University Medical Center (VUmc). He was the founder of the VUmc Cancer Center Amsterdam (CCA) and is advisor to the CCA Board. He served 25 years as chief of the VUmc Department of Oncology and still practices medical oncology.

Dr. Pinedo’s honors are many including the prestigious Dr. Josef Steiner Cancer Research Foundation Award (1995), The Netherland’s Spinoza Prize (1997) and recently the David A. Karnofsky Memorial Award of the American Society of Clinical Oncology (2014). He has received the Knight of the Order of the Netherlands Lion and Commander in the Order of Orange Nassau from Queen Beatrix of the Netherlands. In his honor the annual Pinedo Award for clinical patient care was established in 2006 by the Society of Translational Oncology. He is a member of the Royal Dutch Academy of Science as well as visiting professor at the Johns Hopkins University and the Technical University of Twente, Netherlands. His curriculum vitae includes more than 300 invited lectures, multiple service on boards and committees of numerous European and American organizations, and more than 600 publications as author or coauthor in peer reviewed international journals. He is co-founder of the Center for Translational Molecular Medicine in the Netherlands. He was the first President of the Federation of European Cancer Societies (FECS), the first President and co-founder of European Cancer Organization (ECCO), and Past President to the European Society of Medical Oncology (ESMO). He is past member of the EORTC Board and the ASCO Science Committee. He is Chairman of the International Advisory Committee of the Imaging Center to be established at the VU medical center in Amsterdam with the aim to facilitate targeting agents and personalized medicine for cancer patients in the Netherlands and internationally. Translational cancer research and care for cancer patients are of fundamental importance to Prof. Pinedo.

Advisory board

Professor Yvette van Kooyk chairs the division Dendritic Cell Biology at the VU University Medical Center in Amsterdam. She obtained her PhD cum laude in 1993 at the Medical Faculty of the University of Amsterdam, on her work performed at the Netherlands Cancer Institute, revealing pioneering molecular mechanisms that regulate immune cell adhesion through integrin activation.

In 2001, she discovered the, innate receptor DC-SIGN a C-type lectin on Dendritic cells, playing a crucial role in HIV recognition and cellular interactions through the recognition of glycan structures. This discovery set the stage of a whole new field that led to new concepts on pathogen interactions through C-type lectin receptor, that modify Dendritic cell responses.

Through a Pionier grant she directed her research line into the field of functional glycomics, a field neglected by immunologist, which focuses on the understanding how the exposed glycans on glycoproteins/lipids, are instrumental for the functional activity of proteins, and in cellular communication. She pioneered this field successfully leading to new scientific discoveries, but also to clinical applications into the field of DC-targeting strategies, improving/inhibiting immune responses, and in the field of diagnostics by constructing glycan detection probes for new discovery of tumor associated diseases, linking basic science driven research to translational research. She received ERC-Advanced in 2013 for this research line.

Because her research focus is on conceptual questions that relate to defining DC modifying strategies, her work covers the field of cancer, auto immunity and infectious diseases.

Her current research program comprises 1. “Modulation of immuneresponses by glycans’’ and 2.”DC targeting to improve anti-cancer responses”. She has (co-)authored 220 peer-reviewed publications in international scientific journals and 13 book chapters. Professor van Kooyk has supervised 28 PhD students (1992-2015) of which 2 cum laude and 15 postdoc of which 1 recently became professor. Her current teaching activities involve the coordination of a Bachelor course in Immunology for Biomedical Sciences and Health Sciences and the Research Master Immunology. She received various prestigious grants such as PIONIER and the ERC-Advanced and the van Loghem prize. She is active member of several scientific committees, e.g. board member of the Dutch Society for Immunology, Dutch Cancer Foundation, Board member Cancer Center Amsterdam(CCA) . Finally, she is inventor on 4 patents and is Chief Scientific Officer of the start-up biotech company DC4U